![]() ![]() In Brazil, over-consumption of benzodiazepines can be inferred from the fact that this therapeutic class be responsible for the largest number of poisonings. About formulations with this action, benzodiazepines are used as hypnotics of choice due to its efficacy and safety, being among the most consumed drugs in the world 8. Among the drugs commonly involved in adverse events, we can highlight the psychotropic 7. It is known that the simultaneous use of multiple medications is common in clinical practice and is intrinsically related to the risk of drug interactions and adverse reactions 6. Methods of monitoring and prevention of these events have been evaluated and used as quality indicators in health systems 4,5. The adverse drug events (ADEs) cause health risks to patients causing permanent damage, prolonging hospitalization and increasing health care costs. However, despite the severity of the problem, the development and adoption of safe practices by the healthcare team during training and professional performance are hampered by lack of standardization of concepts in addition to underreporting on the occurrence of adverse events and their causal factors 3. The risk of using drugs in hospitalized patients and implications related to errors in the care process has gained wide prominence in the literature 1,2. Keywords: Flumazenil drug interactions adverse events benzodiazepines. It was observed that advanced age clinical picture with many comorbidities and medication administration with well defined interactions were associated with hipersedation. The method allowed the identification of events requiring the management of excessive sedation associated with the occurrence of potential DI among benzodiazepines and other drugs for a high percentage of patients. In seven cases, there was no prior prescription of benzodiazepines. DI were identified in 84% of these prescriptions. The frequency of indication for reversal of excessive sedation was approximately 1.3 prescriptions per 1,000 patients. ![]() Through the observational method, prescriptions and medical records of 31 patients admitted from June 2008 to June2010 were analyzed concerning the indication for flumazenil, factors that may have contributed to poisoning by benzodiazepines and frequency of DI. ![]() This study focuses on aspects related to the use of flumazenil in hospitalized patients. E-mail: ĪBSTRACT: Drug interactions (DI) exacerbate the risk of serious adverse events related to the use of benzodiazepines. E-mail: PhD in Public Health, Associate Professor, Pharmacy School, Federal University of Rio de Janeiro. E-mail: Master in Public Health, Risk Manager of the University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro. E-mail: PhD in Public Health, Public Health Technologist at the Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. IPharmacist, Specialist in Hospital Pharmacy, Master Student in Applied Science for Health products, Pharmacy School, Federal University Fluminense. Valcieny de Souza Sandes I Guacira Corrêa de Matos II RosanyBochner III Sônia Maria Cezar Góes IV Elisangela da Costa Lima-Dellamora V Factors related to the use of flumazenil in hospitalized patients ![]()
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